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UMR 1332 Biologie du Fruit et Pathologie

Yves Gibon (Dr)

Yves Gibon

Leader of the Metabolism group

Leader of the Hit-Me facility (high throughput metabolic phenotyping platform)

CV :
  • Date of birth : 1968
  • Degree :  2007 Habilitation (Rennes University) ; 1998 PhD in Biology (Rennes University)
  • 1994-1999 Stress Metabolism group (Rennes University); 1999-2001 Stitt group (Heidelberg University); 2001-2008 System Regulation group (Max Planck Institute of Molecular Plant Physiology, Golm-Potsdam); I joined INRA in 2008.

How is metabolism programmed and how does it contribute to plant performance? Such questions make a lot of sense in fruits! As a Physiologist I am interested in using a wide range of approaches to integrate information gathered from various levels. My interest in enzymes led me to work at the development of tools devoted to high throughput analytical biochemistry, which enable us to study metabolism on a large scale (genetic x environmental diversity).

PUBLICATIONS : 2012-2015

Quentin AG, Pinkard EA, Ryan MG, Tissue DT, Baggett LS, Adams HD, Maillard P, Marchand J, Landhäusser SM, Lacointe A, Gibon Y, Anderegg WRL, Asao S, Atkin OK, Bonhomme M, Claye C, Chow PS, Clément-Vidal A, Davies NW, Dickman LT, Dumbur R, Ellsworth DS, Falk K, Galiano L, Grünzweig JM, Hartmann H, Hoch G, Hood S, Jones JE, Koike T, Kuhlmann I, Lloret F, Maestro M, Mansfield SD, Martínez-Vilalta J, Maucourt M, McDowell NG, Moing A, Muller B, Nebauer SG, Niinemets U, Palacio S, Piper F, Raveh E, Richter A, Rolland G, Rosas T, Saint Joanis B, Sala A, Smith RA, Sterck F, Stinziano JR, Tobias M, Unda F, Watanabe M, Way DA, Weerasinghe LK, Wild B, Wiley E & Woodruff DR (2015) Non-structural carbohydrates in woody plants compared among laboratories. Tree Physiology, in press.

Oustric J, Antoine S, Giannettini J, Gibon Y, Luro F, Berti L & SantiniJ (2015) Biochemical characterization of the primary metabolism and antioxidant defense systems of acidic and acidless citrus genotypes during the major stages of fruit growth. Acta Physiologia Plantarum (2015) 37:1-13.

Popova AV, Rausch S, Hundertmark M, Gibon Y & Hincha DK (2015) ] The intrinsically disordered protein LEA7 from Arabidopsis thaliana protects the isolated enzyme lactate dehydrogenase and enzymes in a soluble leaf proteome during freezing and drying. Biochimica et Biophysica Acta-Proteins and Proteomics 1854: 1517-1525.

Rebolledo MC, Dingkuhn M, Courtois B, Gibon Y, Clément-Vidal A, Cruz DF, Duitama J, Lorieux M & Luquet D (2015) Phenotypic and genetic dissection of component traits for early vigour in rice using plant growth modelling, sugar content analyses and association mapping. Journal of Experimental Botany 66: 5555-5566.

Dai ZW, Plessis A, Vincent J, Duchateau N, Besson A, Dardevet M, Prodhomme D, Gibon Y, Hilbert G, Pailloux M, Ravel C & Martre P (2015) Transcriptional and metabolic alternations rebalance wheat grain storage protein accumulation under variable nitrogen and sulfur supply. Plant Journal 83: 326-343.

Saladie M, Canizares J, Phillips MA, Rodriguez-Concepcion M, Larrigaudiere C, Gibon Y, Stitt M, Lunn JE & Garcia-Mas J (2015) Comparative transcriptional profiling analysis of developing melon (Cucumis melo L.) fruit from climacteric and non-climacteric varieties. BMC Genomics 16: #440.

Zhang NY, Gibon Y, Wallace JG, Lepak N, Li PH, Dedow L, Chen C, So YS, Kremling K, Bradbury PJ, Brutnell T, Stitt M & Buckler ES (2015) Genome-Wide Association of Carbon and Nitrogen Metabolism in the Maize Nested Association Mapping Population. Plant Physiology 168: 575-583.

Bénard C, Bernillon S, Biais B, Osorio S, Maucourt M, Ballias P, Deborde C, Colombié S, Cabasson C, Jacob D, Vercambre G, Gautier H, Rolin D, Génard M, Fernie AR, Gibon Y & Moing A (2015) Metabolomic profiling in tomato reveals diel compositional changes in fruit affected by source-sink relationships. Journal of Experimental Botany 66: 3391-3404.

Taulemesse F, Le Gouis J, Gouache D, Gibon Y & Allard V (2015) Post-Flowering Nitrate Uptake in Wheat Is Controlled by N Status at Flowering, with a Putative Major Role of Root Nitrate Transporter NRT2.1. PLOS One 10: #0120291

Khozeai M, Fisk S, Lawson T, Gibon Y, Sulpice R, Stitt M, Lefebvre SC and Raines CA (2015) Overexpression of plastid transketolase in tobacco results in a thiamine auxotrophic phenotype. Plant Cell 27: 432-447.

Colombié S, Nazaret C, Bénard C, Biais B, Mengin V, Solé M, Fouillen L, Dieuaide-Noubhani M, Mazat J-P, Beauvoit B & Gibon Y (2015) Modelling central metabolism by constraint-based optimization reveals reprogramming metabolic fluxes during tomato fruit development. Plant Journal 81: 24-39.

Wallace JG, Bradbury PJ, Zhang NY, Gibon Y, Stitt M & Buckler ES (2015) Association Mapping across Numerous Traits Reveals Patterns of Functional Variation in Maize. PLOS Genetics 10: #1004845.

Desnoues E, Gibon Y, Baldazzi V, Signoret V, Génard M & Quilot-Turion B (2015) Profiling sugar metabolism during fruit development in a peach progeny with different fructose-to-glucose ratios. BMC Plant Biology 14: #336.

Beauvoit B, Colombié S, Monier A, Andrieu M-H, Biais B, Bénard C, Chéniclet C, Dieuaide-Noubhani M, Nazaret C, Mazat J-P & Gibon Y (2014) Model-assisted analysis of sugar metabolism throughout tomato fruit development reveals enzyme and carrier properties in relation to vacuole expansion. Plant Cell 26: 3224-3242.

Recht L, Töpfer N, Batushansky A, Sikron N, Zarka A, Gibon Y, Nikoloski Z, Fait A & Boussiba S (2015) Metabolite profiling and integrative modeling reveal metabolic constraints for carbon partitioning under nitrogen-starvation in the green alga Haematococcus pluvialis. Journal of Biological Chemistry 289: 30387-30403.

Stitt M., Gibon Y. (2014) Why measure enzyme activities in the era of systems biology? Trends in Plant Science, in press.

Gibon Y. (2014) Why bring post genomics into the phosphorus-impoverished bush? Plant Cell & Environment, in press.

Bermudez L, de Godoy F, Baldet P, Demarco D, Osorio S, Quadrana L, Almeida J, Asis R, Gibon Y, Fernie AR, Rossi M & Carrari F (2014) Silencing of the tomato Sugar Partitioning Affecting protein (SPA) modifies sink strength through a shift in leaf sugar metabolism. The Plant Journal 77: 676–687.

Biais B, Bénard C, Beauvoit B, Colombié S, Prodhomme D, Ménard G, Bernillon S, Gehl B, Gautier H, Ballias P, Mazat J-P, Sweetlove L, Génard M & Gibon Y (2014) Remarkable reproducibility of enzyme activity profiles in tomato fruits grown under contrasting environments provides a roadmap for studies of fruit metabolism. Plant Physiology, 164: 1204–1221.

Génard M, Baldazzi V & Gibon Y (2014) Metabolic studies in plant organs: don’t forget dilution by growth. Frontiers in Plant Science 5:#85.

Dumont J, Keski-Saari S, Keinänen M, Cohen D, Ningre N, Kontunen-Soppela S, Baldet P, Gibon Y, Dizengremel P, Vaultier MN, Jolivet Y, Oksanen E & Le Thiec D (2014) Ozone effects on ascorbate and glutathione biosynthesis pathways in relation with amino acid contents on three euramerican poplar genotypes. Tree Physiology, in press.

Pascual L, Xu J, Biais B, Maucourt M ; Ballias P, Bernillon S, Deborde C, Jacob D, Desgroux A, Faurobert M, Bouchet J-P, Gibon Y, Moing A & Causse M (2013) Deciphering genetic diversity and inheritance of tomato fruit weight and composition through a systems biology approach. Journal of Experimental Botany 0(0): doi:10.1093/jxb/ert349

Bernillon S, Biais B, Deborde C, Maucourt M, Cabasson C, Gibon Y, Hansen TH, Husted S, De Vos CH, Mumm R, Jonker H, Ward JL, Miller SJ, Baker JM, Burger J, Tadmor Y, Beale MH, Schjoerring JK, Schäffer AA, Rolin D, Hall RD & Moing A (2013) Metabolomic and elemental profiling of melon fruit quality as affected by genotype and environment. Metabolomics 9: 57-77

Carillo P, Feil R, Gibon Y, Satoh-Nagasawa N, Jackson D, Bläsing OE, Stitt M, Lunn JE (2013) A fluorometric assay for trehalose in the picomole range. Plant Methods 9: 21.

Fontaine JX, Terce-Laforgue T, Armengaud P, Clement G, Renou JP, Pelletier S, Catterou M, Azzopardi M, Gibon Y, Lea PJ, Hirel B & Dubois F (2013) Characterization of a NADH-Dependent Glutamate Dehydrogenase Mutant of Arabidopsis Demonstrates the Key Role of this Enzyme in Root Carbon and Nitrogen Metabolism. Plant Cell 24: 4044-4065.

Ménard G, Biais B, Prodhomme D, Ballias P & Gibon Y (2013) Analysis of Enzyme Activities. In Dieuaide-Noubhani M & Alonso P (eds) Plant Metabolic Flux Analysis. Methods in Molecular Biology Vol. 1090, pp 249-259.

Ménard G, Biais B, Prodhomme D, Ballias P, Petit J, Just D, Rothan C, Rolin D, Gibon Y (2013) High throughput biochemical phenotyping for plants. In Rolin D (ed) Metabolomics coming of age with its technological diversity, book series Advances in Botanical Research Vol 67, pp 407-439.

Sagar M, Chervin C, Mila I, Hao YW, Roustan JP, Benichou M, Gibon Y, Biais B, Maury P, Latche A, Pech JC, Bouzayen M, Zouine M (2013) SlARF4, an Auxin Response Factor Involved in the Control of Sugar Metabolism during Tomato Fruit Development. Plant Physiology 161: 1362-1374.

Sulpice R, Tschoep H, Antonio C, Kleessen S, Larhlimi A, Ishihara H, Nikoloski Z, Gibon Y, Fernie AR, Stitt M (2013) Impact of the carbon and nitrogen supply on the connectivity between metabolism and biomass in a large panel of Arabidopsis accessions. Plant Physiology 162: 347-63.

Tercé-Laforgue T, Bedu M, Dargel-Grafin C, Dubois F, Gibon Y, Restivo FM, Hirel B (2013) Resolving the Role of Plant Glutamate Dehydrogenase: II. Physiological Characterization of Plants Overexpressing the Two Enzyme Subunits Individually or Simultaneously. Plant Cell Physiology 54: 1635-1647.

Dal Santo S, Stampfl H, Krasensky J, Kempa S, Gibon Y, Petutschnig E, Rozhon W, Heuck A, Clausen T & Jonak C (2012) Stress-Induced GSK3 Regulates the Redox Stress Response by Phosphorylating Glucose-6-Phosphate Dehydrogenase in Arabidopsis. Plant Cell 24: 3380-3392.

Fontaine J-X, Tercé-Laforgue T, Armengaud P, Clément G, Renou J-P, Pelletier S, Catterou M, Azzopardi M, Gibon Y, Lea PJ, Hirel B & Dubois F (2012) Characterization of a NADH-Dependent Glutamate Dehydrogenase Mutant of Arabidopsis Demonstrates the Key Role of this Enzyme in Root Carbon and Nitrogen Metabolism. Plant Cell 24: 4044-4065.

Gibon Y, Rolin D, Deborde C, Bernillon S, Moing A (2012) New opportunities in metabolomics and biochemical phenotyping for plant systems biology In U Roessner, ed, Metabolomics, InTech, pp Available from:

Gibon Y, Rolin D (2012) Aspects of experimental design for plant metabolomics experiments and guidelines for growth of plant material. In N Hardy, R Hall, eds, Plant Metabolomics. Methods in Molecular Biology, Humana Press, Totowa, U.S.A., 860:13-30

Hädrich N, Hendriks JH, Kötting O, Arrivault S, Feil R, Zeeman SC, Gibon Y, Schulze WX, Stitt M & Lunn JE (2012) Mutagenesis of cysteine 81 prevents dimerization of the APS1 subunit of ADP-glucose pyrophosphorylase and alters diurnal starch turnover in Arabidopsis thaliana leaves. Plant Journal 70: 231-242.

Poorter H, Fiorani F, Planck M, Schurr U, Finck A, Gibon Y, Usadel B, Munns R, Atkin OK, Tardieu F & Pons TL (2012) The art of growing plants for experimental purposes: a practical guide for the plant biologist. Functional Plant Biology 39: 821-838.