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Charlotte Rey (PhD student under the supervision of Corinne Joffre) was selected to give an oral presentation of her results at the 6th European Workshop on Lipid mediators that will be held 27-30 september 2016 at Francfort. She talked about the resolvins that promote resolution of brain inflammation.

Abstract:

Sustained inflammation in the brain together with microglia activation can lead to neuronal damage. Hence limiting brain inflammation and activation of microglia is a real therapeutic strategy for inflammatory disease. Specialized pro-resolving mediators (SPM) derived from n-3 long chain polyunsaturated fatty acids (n-3PUFA),
such as resolvin D1 (RvD1) and resolvin E1 (RvE1), emerge as key regulators in physiologic pathways since they actively turn off the systemic inflammatory response. RvD1 and RvE1 are produced from the n-3 PUFA docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) respectively. These lipid mediators are synthesized by lipoxygenases (LOX) and cytochrome P450 (CYP450) and exert their anti-inflammatory actions by acting on ALX/fpr2 and ChemR23 receptors. The mechanisms underlying these effects has been poorly described, especially in the central nervous system in microglial cells. Herein, this study aimed to determine in microglial cells the effects
of lipopolysaccharide (LPS)-induced inflammation on the SPM biosynthesis pathways and microglial inflammatory markers and then to examine how RvD1 and RvE1 can modulate LPS-induced inflammation and the mechanisms by which they act.