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Charlotte Rey (étudiante en thèse sous la direction de Corinne Joffre) a été sélectionnée pour faire une communication orale au 6ème Congrès Européen sur les médiateurs lipidiques qui s'est tenu du 27 au 30 septembre 2016 à Francfort. Elle a parlé de l'implication des résolvines dans l'inflammation cérébrale.

Résumé :

Sustained inflammation in the brain together with microglia activation can lead to neuronal damage. Hence limiting brain inflammation and activation of microglia is a real therapeutic strategy for inflammatory disease. Specialized pro-resolving mediators (SPM) derived from n-3 long chain polyunsaturated fatty acids (n-3PUFA),
such as resolvin D1 (RvD1) and resolvin E1 (RvE1), emerge as key regulators in physiologic pathways since they actively turn off the systemic inflammatory response. RvD1 and RvE1 are produced from the n-3 PUFA docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) respectively. These lipid mediators are synthesized by lipoxygenases (LOX) and cytochrome P450 (CYP450) and exert their anti-inflammatory actions by acting on ALX/fpr2 and ChemR23 receptors. The mechanisms underlying these effects has been poorly described, especially in the central nervous system in microglial cells. Herein, this study aimed to determine in microglial cells the effects
of lipopolysaccharide (LPS)-induced inflammation on the SPM biosynthesis pathways and microglial inflammatory markers and then to examine how RvD1 and RvE1 can modulate LPS-induced inflammation and the mechanisms by which they act.